Aromatase inhibitors in men: effects and therapeutic options Reproductive Biology and Endocrinology Full Text

A case study describes a morbidly obese infertile man, who after a similar treatment with anastrozole showed a normalized pituitary-testis axis, spermatogenesis and fertility 46. However, testosterone levels will also improve on weight loss 47, which is the intervention of choice for obese men with or without low testosterone levels. In three small studies, letrozole or testolactone has been administered to morbidly obese men to improve their testosterone levels 42-44. In addition, aromatase inhibitors for men supplements can decrease the effects of excessive estrogen in men already taking supplements to increase Azolol 5mg (400 tabs) buy androgen levels. These effects include gynecomastia (increase in fatty breast tissue) and moodiness. Increased estrogen can destroy the masculine appearance and outlook that many men are seeking.

Given the importance of E2 in male physiology and the impact of TTH on E2, careful monitoring by practitioners providing exogenous therapy is critical. This retrospective study in Indian males showed insignificant effect of AI in gynecomastia and IHH, significant effect in CDP and some benefit in improving seminal parameters. Moreover, this study highlights the importance of estimating E2 (along with T and gonadotropins) in various endocrinopathies, which can be benefitted by reducing E2 by AI. Therefore, inhibiting beta-glucuronidase (via calcium D-glucarate) may help lower levels of estradiol and estrogen metabolites by increasing their rate of elimination 17. So the less aromatase you have, the more testosterone is allowed to remain in its free form.

Phenotype of aromatase deficiency and excess

In addition, a man’s body increases aromatase activity when men have sudden increases in androgen levels. This includes taking testosterone therapy or supplements that increase this hormone. The increase in aromatase is the cause of many of the unwanted side effects of androgen therapy, including gynecomastia, moodiness, impotence, infertility, and a decrease in testicular size. In the Breast International Group’s Femara-Tamoxifen trial, also known as BIG 1–98, 5 years of adjuvant letrozole was compared with 5 years of tamoxifen in postmenopausal women with ER-positive and/or PgR-positive breast cancer. Eventually, this trial was modified with the addition of two treatment groups in which women were either switched from tamoxifen to letrozole or from letrozole to tamoxifen after the initial 2 years of treatment (26).

Cerebral neocortex and hippocampus: cognition, language, and integrative functions

• The potential side effects of natural estrogen blockers are comparatively mild to those of pharmaceutical aromatase inhibitors.
• In postmenopausal women, these compounds are also used in the treatment and prevention of breast cancer.
• (D) Pyramidal neurons in the Pyr of the hippocampal Ammon’s horn CA3 region showing aromatase immunoreactivity in the perikaryon and dendrites.
• The following section will break down the research highlighting naturally occurring compounds that act as estrogen blockers.
• This information is meant to enhance your overall knowledge and is not a replacement for professional medical advice or treatment for particular health issues.
• Overall, we demonstrated a statistically significant reduction in E2 levels to normal physiologic levels with maintenance of T levels, but were unable to identify predictors for men most likely to respond to therapy.

Using aromatase inhibitors can also affect men’s metabolism and cardiovascular health. These changes can be significant and may require lifestyle adjustments or medical interventions to manage effectively. Decreasing Estrogen, such as by consuming natural aromatase inhibitors, can improve many different diseases and symptoms, such as Asthma, Dementia & Alzheimer’s, Depression & Anhedonia, and Hypothyroidism. A deficiency in magnesium increases aromatase, and most people are deficient in this nutrient.

The following section will break down the research highlighting naturally occurring compounds that act as estrogen blockers. Research suggests the common table mushroom has anti-aromatase22 properties and therefore possible anti-estrogen activity. Chinese women who consumed mushrooms and green tea had a 90% lower incidence of breast cancer.23 However the study was relatively small (2,018 patients participating) and limited to Chinese women of southeast China.

The conundrum some men face is that estrogen levels tend to increase as testosterone levels do. As part of the steroidogenesis pathway, testosterone is metabolized into either dihydrotestosterone (DHT) by the 5-alpha reductase enzyme or estradiol by the aromatase enzyme. These case reports illustrate the important contribution of estrogens to male health and identify the possible indications and risks of aromatase-inhibitor treatment in men. They may be used to increase gonadotropin secretion and thereby stimulate Leydig and Sertoli cell function. Aromatase inhibitors may be used to prevent or delay epiphysial closure and thereby increase adult height.